Acupuncture Research Library

Gastrodin and gastrodigenin from Gastrodia elata Blume promote neurogenesis and show therapeutic potential for multiple neurological conditions including Alzheimer's disease, depression, stroke, and amnesia.

This protocol describes a multicenter randomized controlled trial of 181 rheumatoid arthritis patients comparing Tripterygium glycoside tablets alone versus combinations with methotrexate, leflunomide, or hydroxychloroquine, with results pending analysis expected by 2026.

Acupoint catgut embedding significantly reduced fibromyalgia pain in mice by decreasing TRPV1 expression and inflammatory mediators in brain regions associated with pain processing, with effects comparable to genetic deletion of TRPV1.

Electroacupuncture activated SIRT1 to inhibit NF-κB signaling, shifting astrocytes from neurotoxic A1 to neuroprotective A2 phenotype and restoring synaptic integrity after cerebral ischemia-reperfusion injury.

Manual acupuncture with twirling manipulation significantly reduces rheumatoid arthritis pain by inhibiting the NF-κB/STAT3 signaling pathway, thereby decreasing spinal microglia activation and inflammatory cytokine expression.

Electroacupuncture significantly reduced fibromyalgia pain in mice by decreasing Toll-like receptor 4 (TLR4) activation and inflammatory mediators in key brain pain-processing regions including the hypothalamus, periaqueductal gray, and cerebellum.

Amygdalin significantly improved neurological function and reduced brain inflammation after ischemic stroke by specifically targeting the TLR4/NF-κB/NLRP3 inflammasome signaling pathway.

Moxibustion at BL23 and ST36 significantly reduced mitochondrial damage and excessive mitophagy in rheumatoid arthritis rats by inhibiting abnormal PINK1/Parkin pathway activation.

Acupuncture may function as a percutaneous needle fasciotomy that mechanically releases tension in the interconnected fascial network, potentially explaining its therapeutic effects in fibromyalgia through bio-tensegrity principles.

Electroacupuncture promotes angiogenesis and improves functional recovery after ischemic stroke by regulating the miR-214/EZH2/eNOS signaling axis through FTO-dependent m6A modification.

Analysis identified 359 shared genes between rheumatoid arthritis and myositis, with TNF, IL6, and IFNG genes occupying central positions in the protein-protein interaction network, suggesting common inflammatory pathways underlying both conditions.

Acupuncture may improve fibromyalgia symptoms by regulating pain pathway molecules (ASIC3, Nav1.7, Nav1.8, TRPV1), enhancing descending pain inhibition, reducing peripheral inflammation, and modulating autonomic nervous system function.